I have used everything from a thirty-thirty to a 50BMG. I love an -06...and the 308 comes a very close second.
But that was when I would kill my deer out to 250- 300 yards.
Now I prefer the 25 yards or less range...that's the real challenge in my deer hunting. I transitioned from rifles to handguns ...now to the bow. But it's all about the love to hunt no matter how you equip yourself.